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SURVANTA

Ingredient(s): SURVANTA intratracheal suspension is a sterile, non-pyrogenic pulmonary surfactant intended for intratracheal use only. It is a natural bovine lung extract containing phospholipids, neutral lipids, fatty acids, and surfactant-associated protiens to which colfoscerin palmitate (dipalmitoylphosphatidylcholine), palmitic acid, and tripalmitin are added to standardize the composition and to mimic surface-tension lowering properties of natural lung surfactant. The resulting composition provided 25 mg/mL phospholipids (including 11.0 - 15.5 mg/mL disaturated phosphatidylcholine), 0.5-1.75 mg/mL triglycerides, 1.4-3.5 mg/mL free fatty acids, and less than 1.0 mg/mL protein. It is suspended in 0.9% sodium chloride solution, and heat-sterilized. SURVANTA contains no preservatives.Its protein content consists of two hydrophobic, low molecular weight, surfactant-associated protein commonly known as SP-B and SP-C.It does not contain the hydrophilic, large molecular weight sufractant-associated protein known as SP-A.Each mL of SURVANTA contains 25 mg of phospholipids. It is an off-white to light brown liquid supplied in single-use glass vial containing 8 mL (200 mg phospholipids).
Indication(s): Endogenous pulmonary surfactant lowers surface tension on alveolar surfaces during respiration and stabilizes the alveoli against collapse at resting trans-pulmonary pressures. Deficiency of pulmonary surfactant causes Respiratory Distress Syndrome(RDS) in premature infants.SURVANTA replenishes surfactant and restores surface activity to the lungs of these infants.

Pack Size:    1 vial in carton
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